Host cell proteins in biologics manufacturing - A methodical and systematic integration of upstream and downstream processing
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولTechnological and methodical process integration in manufacturing of monoclonal antibodies
Background A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes [1,2]. Concentration and composition of impurities like host cell proteins (HCP) are critical for efficient process development. These impurities show significant variations, which primarily depend on cell cul...
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Trends in Upstream and Downstream Process Development for Antibody Manufacturing.
A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes. Additionally, increasing demands on product quality result in higher complexity of processes and analytics, thereby increasing the costs for product work-up. Concentration and composition of impurities are critical for ...
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ژورنال
عنوان ژورنال: Chemie Ingenieur Technik
سال: 2018
ISSN: 0009-286X
DOI: 10.1002/cite.201855313